|
|
Non-traditional methods of drug administration in anesthesiology and emergency medicine
Kurzová, Alice ; Málek, Jiří (advisor) ; Bláha, Jan (referee) ; Gabrhelík, Tomáš (referee)
1 SUMMARY Introduction The thesis is focused on the research of efficacy and side effects of non-traditional, i.e. nasal administration of oxytocin and nasal and intramuscular administration of remifentanil. Nasal administration has the advantage of being non-invasive and useful in situations with difficult vein access (young children, extensive burns, terrorist attacks and battlefields). The dissertation has two parts that are closely related: nasal, intramuscular and conjunctival administration of remifentanil, nasal and intramuscular administration of oxytocin. Remifentanil is an ultra-short- acting opioid that is registered for intravenous administration only. Its main advantage over other opioids is its rapid metabolism after intravenous administration and absent accumulation even after prolonged infusion. Remifentanil is the only opioid for which, with the exception of two papers, intranasal administration has not been described yet; data on intramuscular and conjunctival administration are completely lacking. Oxytocin is a hormone that is used therapeutically primarily for its peripheral effects in the uterus and breast during pregnancy. However, other central effects have also been observed, i.e. anxiolytic effect, reduction of social stress levels and increase in empathy. It can be useful in...
|
guest ::
